1 BIO: The metabolism of an alcoholic starts converting alcohol into aldehyde, something which is akin to chloroform. Liver, pancreas, kidneys and other essential digestive enzyme seize to work effectively.
2 PSYCHO: There is major memory loss, sense of humour deprivation, reactions become unpredictable (aggression, anger, self pity etc) .
3 Socio: Being inebriated all the time he becomes socially alienated . Actually, an alcoholic himself does not want people to be around him. He perceive people to be useless disturbing predicament to his 'peaceful life '.